Projects & Pilots Archive

Knight ADRC Pilots . Knight ADRC Projects . HASD Projects

archived Knight adrc pilots


2005 - 2006


Genetic Factors Modulating Quantitative Traits in LOAD
Anthony Hinrichs, Psychiatry

Metabolic Consequences of PINK 1 Mutations
Paul Kotzbauer, Neurology


Prospective Memory in DAT and APOE Genotype
Mark McDaniel, Psychology


2004 - 2005


Modulation of the Metabolism of Amyloid Precursor Protein (APP) by IGF-1 Signaling Pathway   
Investigator: Pang-Hsien (Benjamin) Tu, Pathology and Immunology


PET Radiotracer for Imaging Cholinergic Terminal Function in AD
Investigator: Zhude Tu, Radiology


Aging & Implicit Memory: Task Demands & Neurological Functioning
Investigator: Lisa Geraci, Psychology 


Roles of Neuregulin-1 in Age-Related Neuronal Changes
Investigator: Jianxin Bao, Otolaryngology


2003 - 2004


Toward a Molecular Understanding of Polyglutamine Disorders   
Investigator: Rohit Pappu, Biomedical Engineering 


Event Perception in Healthy Aging and Mild Dementia of the Alzheimer's Type
Investigator: Jeff Zacks, Psychology 


Impact of Stroke on Psychometric Performance in Normal and Mildly Demented Individuals
Investigator: Alex Dromerick, Neurology 


Acute and Chronic Effect of ß-Amyloid on Arteriolar Regulation
Investigator: Hans Dietrich, Neurosurgery 


Cerebral Microhemorrhage in Patients with Alzheimer's Disease
Investigator: Jin-Moo Lee, Neurology 


Role of Ubiquitination in Axonal Degeneration
Investigator: Toshiyuki Araki, Pathology & Immunology (Milbrandt Lab)


Does Repetitive Mild Traumatic Brain Injury Cause Long-Term Cognitive Impairment
Investigator: Lawrence Lewis, Emergency Medicine 


2002 - 2003


Identifying compounds that delay the age-related degenerative changes in Caenorhabditis elegans
Principle Investigator: Kerry Kornfeld


Effects of the APP mutation on the brain's normal capacity for neurogenesis
Principle Investigator: John Csernansky


Molecular pathways of death in grafted dopamine neurons
Principle Investigator: Gabriel A. de Erausquin


Computerized dynamic posturography (CDP) and mildly impaired subject balance
Principle Investigator: John W. Rohrbaugh


Archived knight adrc projects


2010 - 2015


Novel protein biomarkers for Alzheimer’s disease in cerebrospinal fluid
Richard Perrin


Changing tau protein levels and tau protein isoforms in mouse models of dementia
Timothy Miller


APOE metabolism in AD and controls
Randall Bateman


2005 - 2010


Mapping substrate/y-secretase interactions 
Project Leader: Rahpael Kopan, Ph.D. 

PET Amyloid Imaging in the Elderly to Evaluate DAT Risk 
Project Leader: Mark Mintun, MD 

2000 - 2005


Identification of Genes that Modify Age of Onset of AD
Project Leader: Alison M. Goate

CNS apolipoprotein J: Role in Aß deposition
Project Leader: David M. Holtzman

Role of LRP and its Ligand tPA in LTP and Aging
Project Leader: Guojun Bu, Ph.D.

tMRI Exploration of Memory in Aging and Early-Stage DAT
Project Leader: Randy L. Buckner


Archived HASD projects


2009 - 2013


Project 1 Preclinical AD predicts poststroke dementia
John C. Morris, MD


Project 2 Antecedent biomarkers of AD in CSF and plasma
David Holtzman, MD


Project 3 Markers for DAT: Control, variability, and personality
David Balota, Ph.D.


Project 4 Sequence variation in genes for biomarker proteins and age at onset
Alison Goate, DPhil


2004 - 2009


Informant-based dementia diagnosis in an African American community 
John C. Morris, MD

Biomarkers for pre-clinical and clinical AD
David M. Holtzman, MD


Attention in Healthy Aging & Early Stage DAT
David Balota, Ph.D.

1998 - 2003


Intellect and Alzheimer changes in the very old
Project Leader: John C. Morris


Mapping of Neuropathology in Healthy Aging and Dementia
Project Leader: Joseph L. Price


Frontal Control Systems and Memory in Aging and DAT
Project Leader: David A. Balota


Imaging Neuronal Loss with MRI/MRS in DAT and Controls
Project Leader: Benjamin Lee