Knight ADRC Projects & Pilots
Call for Pilot Research Grant Applications
The 2011 call for applications is currently closed. Check back Fall 2012 for the next call for applications.
Alzheimer’s Disease Research Center (5-1-10 to 4-30-15):
Novel protein biomarkers for Alzheimer’s disease in cerebrospinal fluid
Richard Perrin
Changing tau protein levels and tau protein isoforms in mouse models of dementia
Timothy Miller
APOE metabolism in AD and controls
Randall Bateman
Healthy Aging & Senile Dementia Program Project (5-15-09 to 12-31-13):
Project 1 Preclinical AD predicts poststroke dementia
John C. Morris, MD
Project 2 Antecedent biomarkers of AD in CSF and plasma
David Holtzman, MD
Project 3 Markers for DAT: Control, variability, and personality
David Balota, Ph.D.
Project 4 Sequence variation in genes for biomarker proteins and age at onset
Alison Goate, DPhil
5/10 - 4/11
Effect of endogenous amyloid-β on synaptic plasticity in vivo.
John R. Cirrito, PhD
Risk of falls in preclinical Alzheimer's disease: a prospective study.
Susan L. Stark, PhD
Selective PET tracers for human Cerebral Amyloid Angiopathy.
Gregory J. Zipfel
Funded through gift funds:
Selective labels for tau fibrils.
Marc I. Diamond, MD
5/09 - 4/10
Beau Ances
Role of TOR3A as a regulator of Aβ production.
Phyllis Hanson
Developing antisense oligonucleotides to modify tau in mouse models of dementia.
Timothy Miller
5/08 - 4/09
Axonal Transport of APP: The Role of the Mixed Lineage Kinase DLKAaron DiAntonio
Proteasomal Impairment by Mutant Ubiquitin and Enhanced Toxicity of Aggregates
Heather True-Krob
Mishandling of protein aggregates in p97/VCP associated fronto-temporal dementia.
Conrad Weih
Funded through gift funds:
Analysis of beta secretase activity and APP processing in GGA knockout mice.
Balraj Doray
5/07 – 4/08
Vijay Sharma, Radiology
Neurology and Radiology, Use of 11C-PIB to determine risk of recurrence of lobar intracerebral hemorrhage: A pilot study.
Allyson Zazulia
Roles of Aβtype lamins on telomere metabolism and premature aging.
Susana Gonzalo
5/06 – 4/07:
Eye movements during visual search in healthy aging and very mild DAT
Richard A. Abrams, PhD
Emotional Aging: Preservation of Function in the Elderly and Alzheimer's Patients
Randy J. Larsen, PhD
Selective synapse loss and β-amyloid deposition in the Tg2576 mouse
Hongxin Dong, MD PhD
5/05 – 4/06:
Genetic Factors Modulating Quantitative Traits in LOAD
Anthony Hinrichs, Psychiatry
Metabolic Consequences of PINK 1 Mutations
Paul Kotzbauer, Neurology
Prospective Memory in DAT and APOE Genotype
Mark McDaniel, Psychology
PK11195 PET imaging of inflammation in aging and DAT
Mark Mintun, Director of Center for Clinical Imaging Research
Mutant Valosin-Containing Protein Causes Neurodegeneration and Frontotemporal Dementia
Nigel Cairns, Neurology
