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Current Projects • Current & Recent Pilots • Archive
Current Projects
Alzheimer’s Disease Research Center (2005-2010):
Project 1 Mapping substrate/y-secretase interactions
Rahpael Kopan, Ph.D. (Project Leader)
Project 3 PET Amyloid Imaging in the Elderly to Evaluate DAT Risk
Mark Mintun, MD
Healthy Aging & Senile Dementia Program Project (2004-2008):
Project 1 Dementia Assessment in the Community
John C. Morris, MD
Project 2 Novel Biomarkers to Predict Alzheimer's Disease
David Holtzman, MD
Project 3 Attention Profiles in Healthy Aging and Early State DAT
David Balota, Ph.D.
Project 4 Predicting Cognitive Decline in Nondemented Elder Subjects
John Csernansky, MD
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Current & Recent Pilots
5/09 - 4/10
Interaction
Between HIV and Aging Using 11C-labeled Pittsburgh Compound-B
(11C-PIB)
Beau Ances
Role of
TOR3A as a regulator of Aβ production.
Phyllis Hanson
Developing antisense oligonucleotides to modify tau in mouse models
of dementia.
Timothy Miller
5/08 - 4/09
Axonal
Transport of APP: The Role of the Mixed Lineage Kinase DLK
Aaron DiAntonio
Proteasomal
Impairment by Mutant Ubiquitin and Enhanced Toxicity of Aggregates
Heather True-Krob
Mishandling of
protein aggregates in p97/VCP associated fronto-temporal dementia.
Conrad Weih
Funded through gift funds:
Analysis of beta secretase activity and APP
processing in GGA knockout mice.
Balraj Doray
5/07 – 4/08
PET Agent for
Imaging of P-glycoprotein (Pgp) mediated transport activity in
Alzheimer’s disease.
Vijay
Sharma, Radiology
Neurology and
Radiology, Use of 11C-PIB to determine risk of recurrence of
lobar intracerebral hemorrhage: A pilot study.
Allyson
Zazulia
Roles of
Aβtype lamins on telomere metabolism and premature aging.
Susana
Gonzalo
5/06 – 4/07:
Eye movements during visual search in healthy aging and very mild DAT
Richard A. Abrams, PhD
Emotional Aging: Preservation of Function in the Elderly and Alzheimer's Patients
Randy J. Larsen, PhD
Selective synapse loss and β-amyloid deposition in the Tg2576 mouse
Hongxin Dong, MD PhD
5/05 – 4/06:
Genetic Factors Modulating Quantitative Traits in LOAD
Anthony Hinrichs, Psychiatry
Metabolic Consequences of PINK 1 Mutations
Paul Kotzbauer, Neurology
Prospective Memory in DAT and APOE Genotype
Mark McDaniel, Psychology
PK11195 PET imaging of inflammation in aging and DAT
Mark Mintun, Director
of Center for Clinical Imaging Research
Mutant Valosin-Containing
Protein Causes Neurodegeneration and Frontotemporal Dementia
Nigel Cairns, Neurology
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