The Charles F. and Joanne Knight Alzheimer's Disease Research Center

Call for Pilot Research Grant Applications

The call for applications is currently closed.

Current Projects

Alzheimer’s Disease Research Center (5-1-10 to 4-30-15):

Novel protein biomarkers for Alzheimer’s disease in cerebrospinal fluid
Richard Perrin

Changing tau protein levels and tau protein isoforms in mouse models of dementia
Timothy Miller

APOE metabolism in AD and controls
Randall Bateman

Healthy Aging & Senile Dementia Program Project (5-15-09 to 12-31-13):

Project 1 Preclinical AD predicts poststroke dementia
John C. Morris, MD

Project 2 Antecedent biomarkers of AD in CSF and plasma
David Holtzman, MD

Project 3 Markers for DAT: Control, variability, and personality
David Balota, Ph.D.

Project 4 Sequence variation in genes for biomarker proteins and age at onset
Alison Goate, DPhil

Current & Recent Pilots

5/10 - 4/11

Effect of endogenous amyloid-β on synaptic plasticity in vivo.
John R. Cirrito, PhD

Risk of falls in preclinical Alzheimer's disease: a prospective study.
Susan L. Stark, PhD

Selective PET tracers for human Cerebral Amyloid Angiopathy.
Gregory J. Zipfel

Funded through gift funds:
Selective labels for tau fibrils.
Marc I. Diamond, MD

5/09 - 4/10

Interaction Between HIV and Aging Using 11C-labeled Pittsburgh Compound-B (11C-PIB)
Beau Ances

Role of TOR3A as a regulator of Aβ production.
Phyllis Hanson

Developing antisense oligonucleotides to modify tau in mouse models of dementia.
Timothy Miller

5/08 - 4/09

Axonal Transport of APP: The Role of the Mixed Lineage Kinase DLK
Aaron DiAntonio

Proteasomal Impairment by Mutant Ubiquitin and Enhanced Toxicity of Aggregates
Heather True-Krob

Mishandling of protein aggregates in p97/VCP associated fronto-temporal dementia.
Conrad Weih

Funded through gift funds:

Analysis of beta secretase activity and APP processing in GGA knockout mice.
Balraj Doray

5/07 – 4/08

PET Agent for Imaging of P-glycoprotein (Pgp) mediated transport activity in Alzheimer’s disease.
Vijay Sharma, Radiology

Neurology and Radiology, Use of 11C-PIB to determine risk of recurrence of lobar intracerebral hemorrhage: A pilot study.
Allyson Zazulia

Roles of Aβtype lamins on telomere metabolism and premature aging.
Susana Gonzalo

5/06 – 4/07:

Eye movements during visual search in healthy aging and very mild DAT
Richard A. Abrams, PhD

Emotional Aging: Preservation of Function in the Elderly and Alzheimer's Patients
Randy J. Larsen, PhD

Selective synapse loss and β-amyloid deposition in the Tg2576 mouse
Hongxin Dong, MD PhD

5/05 – 4/06:

Genetic Factors Modulating Quantitative Traits in LOAD
Anthony Hinrichs, Psychiatry

Metabolic Consequences of PINK 1 Mutations
Paul Kotzbauer, Neurology

Prospective Memory in DAT and APOE Genotype
Mark McDaniel, Psychology

PK11195 PET imaging of inflammation in aging and DAT
Mark Mintun, Director of Center for Clinical Imaging Research

Mutant Valosin-Containing Protein Causes Neurodegeneration and Frontotemporal Dementia
Nigel Cairns, Neurology