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5th Leonard Berg Symposium
Antecedent Biomarkers for Early & Preclinical
Detection of Alzheimer's Disease
October 7-8, 2005
Eric P. Newman Education Center
Sponsored by:
Alzheimer's Disease Research Center
Department of Neurology
Washington University School of Medicine
Supported in part by an unrestricted educational grant from Pfizer, Inc.
About the Event:
The 5th Leonard Berg Symposium will take place on October 7-8, 2005, at the Eric P. Newman Education Center on the campus of Washington University School of Medicine. This 2-day conference will review current and emerging findings concerning: (1) Risk factors for Alzheimer's disease (AD) identified in pre-clinical and early clinical stages; (2) Genetic markers for AD development and progression; (3) Preclinical detection of AD though the use of antecedent biomarkers & related neuroimaging techniques.
Target Audience:
Physicians, dementia specialists, neuroscientists, university medical/science faculty, advanced trainees (i.e., graduate students, fellows, medical residents), scientists and professionals from industry, neuropsychologists, and other professional or lay individuals with interests in antecedent biomarkers and/or the early detection of dementing disorders.
Objectives of the Symposium:
Program Schedule:
Thursday, October 6, 2005
Registration Desk Opens & Poster Session Setup
5:00 – 7:00 PM, Lobby, EP Newman Education Center, WUSM
Pre-Symposium Reception for Friends of the ADRC (by invitation only)
5:00 – 6:00 PM, Great Room A, EP Newman Center, WUSM
Pre-Symposium Faculty & Friends Dinner (by invitation only)
6:00 – 8:00 PM, Location EP Newman Center, WUSM
Friday, October 7, 2005
Session 1: Risk Factors for Preclinical Alzheimer’s Disease |
7:30 AM |
Registration Desk Opens & Continental Breakfast (Lobby, EP Newman Education Center)
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8:15 |
Welcome & Opening Remarks
John C. Morris, MD, Friedman Distinguished Professor of Neurology
Principal Investigator & Director, Alzheimer’s Disease Research Center, WUSM
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8:30 |
The Epidemiological Perspective
Claudia H. Kawas, MD, Professor of Neurology, and Neurobiology & Behavior
University of California – Irvine
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9:15 |
Predictors of Alzheimer’s Disease
Kristine Yaffe, MD, Associate Professor of Psychiatry, Neurology, and Epidemiology & Biostatistics
University of California – San Francisco
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10:00 |
Break (beverage & snack)
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10:30 |
Clinical-Cognitive Markers from a Longitudinal Study of Aging & Dementia
James Galvin, MD, MPH, Assistant Professor of Neurology, WUSM
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11:15 |
Q & A Panel (Moderator: John C. Morris, MD)
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11:45 PM |
Buffet Luncheon (Great Rooms A & B)
KEYNOTE ADDRESS
12:30 – 1:00 PM
A Brief History of Alzheimer’s Disease Research in the United States
Zaven Khachaturian, PhD, Khachaturian, Radebaugh & Associates, Inc.
Note: Due to space constraints in the dining area, some attendees from Washington University will be asked to eat in the main auditorium and watch this presentation via close circuit TV.
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Session 2: Genetic Markers of Alzheimer’s Disease |
1:15 |
Genetic Factors as Antecedent Markers for Alzheimer’s Disease
Alison M. Goate, DPhil, Professor of Psychiatry and Genetics, WUSM
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2:00 |
Quantitative Traits in Complex Diseases: The Cardiovascular Disease Perspective
Laura Almasy, PHD, Associate Scientist, Dept. of Genetics, Southwest Foundation for Biomedical Research
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2:45 |
The Application of Genomic & Proteomic Techniques in Cancer
Jeffrey Milbrandt , MD, Professor of Pathology & Immunology, WUSM
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| 3:30 |
Alzheimer's Biomarker Knowledge Base Project
Sherrilynne Fuller, PhD, Professor of Medical Education & Biomedical Informatics, University of Washington
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3:45 |
Break
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Special Session: Celebrating AD Research – Past & Future |
4:00 |
The NIA Alzheimer’s Disease Centers Program
Marcelle Morrison-Bogorad, PhD, Director, Neuroscience and Neuropsychology of Aging Program, National Institute on Aging
Creighton Phelps, PhD, Director, Alzheimer’s Disease Centers Program, National Institute on Aging
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4:20 |
Alzheimer’s Disease Research at Washington University: 20 Years of Teamwork & Discovery
John C. Morris, MD, Friedman Distinguished Professor of Neurology
Principal Investigator & Director, Alzheimer’s Disease Research Center, WUSM
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4:40 |
Personal Reflections on Alzheimer’s Disease Research
Leonard Berg, MD, Professor Emeritus of Neurology, & Founding Director, ADRC, WUSM
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5:00 – 6:30 |
Reception & Poster Session (Lobby)
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7:00 |
Faculty Dinner (Bar Italia, 13 Maryland Plaza, Central West End, St. Louis - MAP)
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Saturday, October 8, 2005
Session 3: Antecedent Biomarkers for Alzheimer’s Disease |
| 7:00 AM |
Biomarkers Working Group Meeting & Breakfast (closed meeting, by invitation only) |
7:30 |
Registration Desk Opens & Continental Breakfast (Lobby, EP Newman Education Center)
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8:30 |
Welcome & Opening Remarks
Eugene M. Johnson, Jr., PhD, Stupp Professor of Neurology; Professor of Molecular Biology & Pharmacology, WUSM
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| 8:40 |
Lifestyle Factors and the Search for Antecedent Biomarkers: A Clinician's Perspective
Eric B. Larson, MD, MPH, FACP, Professor of Medicine, University of Washington School of Medicine |
9:25 |
Antecedent Biomarkers for AD: Data from Unbiased & Biased Approaches
David Holtzman, M.D., Chair and Hagemann Professor of Neurology, WUSM
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10:10 |
BREAK(beverage & snack)
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10:30 |
Identifying Candidate Biomarkers for AD: An Industry Perspective
Howard Schulman, PhD, Vice President of Research and Development, SurroMed, Inc.
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11:15 |
NIA Alzheimer’s Disease Neuroimaging Initiative - Biomarkers Program
John Trojanowski, MD, Professor of Pathology & Laboratory Medicine; Director, Institute on Aging
Director, Alzheimer's Disease Center; Co-director, Center for Neurodegenerative Disease Research; University of Pennsylvania
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12:00 |
Buffet Luncheon (Great Rooms A & B)
KEYNOTE ADDRESS
12:30 – 1:15 PM
Alzheimer's Disease Research: The Next 20 Years
Dennis Selkoe, MD, Vincent & Stella Coates Professor of Neurologic Diseases, Harvard Medical School & Brigham and Women's Hospital
Note: Due to space constraints in the dining area, some attendees from Washington University will be asked to eat in the main auditorium and watch this presentation via close circuit TV.
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Session 4: Neuroimaging and the Detection of Preclinical Alzheimer’s Disease |
1:30 |
Structural & Functional Neuroimaging for Preclinical Detection
Randy Buckner, Ph.D., Associate Professor of Psychology & Radiology, Washington University
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2:15 |
Benzothiazole Amyloid-Imaging Agents
William E. Klunk, M.D., Ph.D., Associate Professor of Psychiatry, University of Pittsburgh
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| 3:00 |
PIB Imaging at Washington University
Mark Mintun, MD, Professor of Radiology & Psychiatry, WUSM |
3:30 |
Q & A Panel (Moderator: John C. Morris, MD)
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| 4:00 |
Closing Remarks & Evaluation
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5:30 |
Faculty Dinner (location TBA) |
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