The Charles F. and Joanne Knight Alzheimer's Disease Research Center

5th Leonard Berg Symposium

5th Leonard Berg Symposium
Antecedent Biomarkers for Early & Preclinical
Detection of Alzheimer's Disease
October 7-8, 2005
Eric P. Newman Education Center
Sponsored by:
The Charles F. and Joanne Knight Alzheimer's Disease Research Center
Department of Neurology
Washington University School of Medicine
Supported in part by an unrestricted educational grant from Pfizer, Inc.

About the Event:

The 5th Leonard Berg Symposium will take place on October 7-8, 2005, at the Eric P. Newman Education Center on the campus of Washington University School of Medicine. This 2-day conference will review current and emerging findings concerning: (1) Risk factors for Alzheimer's disease (AD) identified in pre-clinical and early clinical stages; (2) Genetic markers for AD development and progression; (3) Preclinical detection of AD though the use of antecedent biomarkers & related neuroimaging techniques.

Target Audience:

Physicians, dementia specialists, neuroscientists, university medical/science faculty, advanced trainees (i.e., graduate students, fellows, medical residents), scientists and professionals from industry, neuropsychologists, and other professional or lay individuals with interests in antecedent biomarkers and/or the early detection of dementing disorders.

Objectives of the Symposium:

To review current and emerging findings concerning:
1. Risk factors for Alzheimer’s disease (AD) identified in pre-clinical and early clinical stages;
2. Genetic markers for AD development and progression;
3. Preclinical detection of AD through the use of antecedent biomarkers and related neuroimaging imaging techniques.

Program Schedule:

Friday, October 7, 2005

Session 1: Risk Factors for Preclinical Alzheimer’s Disease
7:30 AM	Registration Desk Opens & Continental Breakfast (Lobby, EP Newman Education Center)
8:15	Welcome & Opening Remarks John C. Morris, MD, Friedman Distinguished Professor of Neurology Principal Investigator & Director, Alzheimer’s Disease Research Center, WUSM
8:30	The Epidemiological Perspective Claudia H. Kawas, MD, Professor of Neurology, and Neurobiology & Behavior University of California – Irvine
9:15	Predictors of Alzheimer’s Disease Kristine Yaffe, MD, Associate Professor of Psychiatry, Neurology, and Epidemiology & Biostatistics University of California – San Francisco
10:00	Break (beverage & snack)
10:30	Clinical-Cognitive Markers from a Longitudinal Study of Aging & Dementia James Galvin, MD, MPH, Assistant Professor of Neurology, WUSM
11:15	Q & A Panel (Moderator: John C. Morris, MD)
11:45 PM	Buffet Luncheon (Great Rooms A & B) KEYNOTE ADDRESS 12:30 – 1:00 PM A Brief History of Alzheimer’s Disease Research in the United States Zaven Khachaturian, PhD, Khachaturian, Radebaugh & Associates, Inc. Note: Due to space constraints in the dining area, some attendees from Washington University will be asked to eat in the main auditorium and watch this presentation via close circuit TV.
Session 2: Genetic Markers of Alzheimer’s Disease
1:15	Genetic Factors as Antecedent Markers for Alzheimer’s Disease Alison M. Goate, DPhil, Professor of Psychiatry and Genetics, WUSM
2:00	Quantitative Traits in Complex Diseases: The Cardiovascular Disease Perspective Laura Almasy, PHD, Associate Scientist, Dept. of Genetics, Southwest Foundation for Biomedical Research
2:45	The Application of Genomic & Proteomic Techniques in Cancer Jeffrey Milbrandt , MD, Professor of Pathology & Immunology, WUSM
3:30	Alzheimer's Biomarker Knowledge Base Project Sherrilynne Fuller, PhD, Professor of Medical Education & Biomedical Informatics, University of Washington
3:45	Break
Special Session: Celebrating AD Research – Past & Future
4:00	The NIA Alzheimer’s Disease Centers Program Marcelle Morrison-Bogorad, PhD, Director, Neuroscience and Neuropsychology of Aging Program, National Institute on Aging Creighton Phelps, PhD, Director, Alzheimer’s Disease Centers Program, National Institute on Aging
4:20	Alzheimer’s Disease Research at Washington University: 20 Years of Teamwork & Discovery John C. Morris, MD, Friedman Distinguished Professor of Neurology Principal Investigator & Director, Alzheimer’s Disease Research Center, WUSM
4:40	Personal Reflections on Alzheimer’s Disease Research Leonard Berg, MD, Professor Emeritus of Neurology, & Founding Director, Knight ADRC, WUSM
5:00 – 6:30	Reception & Poster Session (Lobby)
7:00	Faculty Dinner (Bar Italia, 13 Maryland Plaza, Central West End, St. Louis)

Saturday, October 8, 2005

Session 3: Antecedent Biomarkers for Alzheimer’s Disease
7:00 AM	Biomarkers Working Group Meeting & Breakfast (closed meeting, by invitation only)
7:30	Registration Desk Opens & Continental Breakfast (Lobby, EP Newman Education Center)
8:30	Welcome & Opening Remarks Eugene M. Johnson, Jr., PhD, Stupp Professor of Neurology; Professor of Molecular Biology & Pharmacology, WUSM
8:40	Lifestyle Factors and the Search for Antecedent Biomarkers: A Clinician's Perspective Eric B. Larson, MD, MPH, FACP, Professor of Medicine, University of Washington School of Medicine
9:25	Antecedent Biomarkers for AD: Data from Unbiased & Biased Approaches David Holtzman, M.D., Chair and Hagemann Professor of Neurology, WUSM
10:10	BREAK(beverage & snack)
10:30	Identifying Candidate Biomarkers for AD: An Industry Perspective Howard Schulman, PhD, Vice President of Research and Development, SurroMed, Inc.
11:15	NIA Alzheimer’s Disease Neuroimaging Initiative - Biomarkers Program John Trojanowski, MD, Professor of Pathology & Laboratory Medicine; Director, Institute on Aging Director, Alzheimer's Disease Center; Co-director, Center for Neurodegenerative Disease Research; University of Pennsylvania
12:00	Buffet Luncheon (Great Rooms A & B) KEYNOTE ADDRESS 12:30 – 1:15 PM Alzheimer's Disease Research: The Next 20 Years Dennis Selkoe, MD, Vincent & Stella Coates Professor of Neurologic Diseases, Harvard Medical School & Brigham and Women's Hospital Note: Due to space constraints in the dining area, some attendees from Washington University will be asked to eat in the main auditorium and watch this presentation via close circuit TV.
Session 4: Neuroimaging and the Detection of Preclinical Alzheimer’s Disease
1:30	Structural & Functional Neuroimaging for Preclinical Detection Randy Buckner, Ph.D., Associate Professor of Psychology & Radiology, Washington University
2:15	Benzothiazole Amyloid-Imaging Agents William E. Klunk, M.D., Ph.D., Associate Professor of Psychiatry, University of Pittsburgh
3:00	PIB Imaging at Washington University Mark Mintun, MD, Professor of Radiology & Psychiatry, WUSM
3:30	Q & A Panel (Moderator: John C. Morris, MD)
4:00	Closing Remarks & Evaluation
5:30	Faculty Dinner (location TBA)